Prediction of the course of hypoandrogenism in adolescent boys

The most pathological conditions that adversely affect the reproductive function in men of mature age is formed precisely adolescence as a result from hypoandrogenism (HA), - decrease production male sex hormones (androgens) below norm. Therefore, ability to predict course HA adolescent boys allows prevent serious health problems future. Purpose determine significant prognostic criteria for adverse with delayed sexual development. Materials and methods. Were examined 157 14-17 years old signs androgen deficiency, degree which was based on assessment total testosterone (TT). levels gonadotropic hormones, estradiol, their ratios were studied by enzyme-linked immunosorbent assay, content thyroid-stimulating hormone free thyroxine, ratio determined. lipid spectrum blood studied. On basis X-rays non-dominant hand wrist determined bone ossification deficiency. Сonditionally unfavorable severe deficiency (HA 3 degree) at level <4 nmol/l. Favorable considered be presence clinical adolescents normal TT, more than 12 nmol/l 0 degree). Results. Based study identified informative features calculated coefficient. It proved are such body mass index abnormalities, deficit, estradiol values / luteinizing ratios, thyroid stimulating changes profile. To prognostically negative excess weight level, deficit (more years), decreased levels, follicle ratio, hyperestrogenism, pronounced androgenic-estrogenic disbalance, minimal dysfunction, disorders Conclusions. developed will make it possible further disease (in early stages its formation pathology), what carry out timely treatment rehabilitation measures boys, this help improve health. Teens HA, who show signs, need careful dispensary observation an endocrinologist. research carried accordance principles Helsinki Declaration. protocol approved Local Ethics Committee all participating institutions. informed consent patient obtained conducting studies. No conflict interests declared authors.